Diabetes and aortic dissection: unraveling the role of 3-hydroxybutyrate through mendelian randomization
Authors' conclusion
Mendelian randomization study revealed diabetes as a protective factor for dissection of aorta. The protective effect of type 1 diabetes on aortic dissection was partially mediated by 3-hydroxybutyrate, but type 2 diabetes was not 3-hydroxybutyrate mediated.
Study context
- Population
- Publicly accessible GWAS data for T1D, T2D, dissection of aorta and 3-hydroxybutyrate
- Comparison
- Genetically predicted T1D and T2D vs aortic dissection risk, mediation by 3-hydroxybutyrate
- Outcome
- Causal effect of diabetes on risk of aortic dissection and mediating role of 3-hydroxybutyrate
Methodological detailstwo-step Mendelian randomization, mediation analysis, GWAS summary data
- Two-step Mendelian randomization
- Mediation analysis
- GWAS summary data
Main finding
As reported in the abstract
Aortic dissection
T1D and risk of aortic dissection (IVW), OR
0.912 (0.836-0.995) (95% CI)
T2D and risk of aortic dissection (IVW), OR
0.763 (0.607-0.960) (95% CI)
Further findings
- Mediated proportion of 3-hydroxybutyrate, T1D–aortic dissection
- 24.80% (5.12-44.47%) (95% CI)
- 3-Hydroxybutyrate has no causal mediation effect on T2D–aortic dissection
Original publication
Diabetes and aortic dissection: unraveling the role of 3-hydroxybutyrate through mendelian randomization. Cardiovasc Diabetol. Published 7 May 2024. doi:10.
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