The Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes
Main findingResult — go to the resultAdjusted risk 4.234 95% CI 3.089–5.803Authors' conclusion
The prevalence of MUNW is 14% in Chinese normal-weight nondiabetic individuals, and active intervention is necessary for this category of people. The presence of MUNW significantly increases the risk of diabetes, and the risk of diabetes is associated with the number of MetS components present in the patient.
Study context
- Population
- Nondiabetic normal-weight individuals, Rich Healthcare Group, China
- Participants
- 63,830 individuals
- Exposure
- Metabolically unhealthy normal weight (MUNW) vs metabolically healthy normal weight
- MUNWn = 8,935
- Outcome
- Prevalence of MUNW and its predictive effect on incident diabetes
- Follow-up
- Average 3.10 years
Methodological detailsnationally representative
- Nationally representative
Main finding
As reported in the abstract
average 3.10 years
Adjusted risk
4.234
95% CI 3.089–5.803
- Prevalence of MUNW
- 8935 (14.0%)
- Diagnosed with metabolic syndrome (MetS)
- 1916 (3.00%)
Observational data: associations, not effects.
Further findings
| Outcome | Multivariable-adjusted HR (95% CI) | |
|---|---|---|
| Incident diabetes by number of MetS components · average 3.10 years follow-up1 componentvs No components | 3.069 (1.790–5.263) | |
| Incident diabetes by number of MetS components · average 3.10 years follow-up2 componentsvs No components | 7.990 (4.668–13.677) | |
| Incident diabetes by number of MetS components · average 3.10 years follow-up3 or more componentsvs No components | 11.950 (6.618–21.579) | |
| Incident diabetes by number of MetS components, subgroup aged ≤44 years1 componentvs No components | 4.45 (1.45–13.72) | |
| Incident diabetes by number of MetS components, subgroup aged ≤44 years2 componentsvs No components | 9.82 (3.05–31.64) | |
| Incident diabetes by number of MetS components, subgroup aged ≤44 yearsAt least 3 componentsvs No components | 15.13 (3.70–61.84) | |
| Incident diabetes by number of MetS components, male subgroup1 componentvs No components | 3.55 (1.81–6.97) | |
| Incident diabetes by number of MetS components, male subgroup2 componentsvs No components | 8.52 (4.34–16.73) | |
| Incident diabetes by number of MetS components, male subgroupAt least 3 componentsvs No components | 13.69 (6.51–28.77) | |
| 0.050.21520Multivariable-adjusted HR (log scale) |
Original publication
The Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes. J Clin Endocrinol Metab. Published 14 March 2023. doi:10.
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