Trabecular bone deficits predominate in the appendicular skeleton of midlife women living with HIV: findings from a cross-sectional study in Zimbabwe
Authors' conclusion
Trabecular deficits predominate in WLH, though with age cortical compartment bone loss may increase in importance.
Study context
- Population
- Women aged 40–60 yr in Harare, Zimbabwe (49% women living with HIV (WLH)); mean (SD) age 49.7 (5.8) yrhad peripheral QCT (pQCT) data
- Participants
- 384 women
- Exposure
- Women living with HIV vs women without HIV
- Outcome
- pQCT bone measures by HIV status (adjusted for age, menopause status, height and fat mass)
Main finding
As reported in the abstract
Each group vs without HIVEstimate (CI)
WLH
difference in radius trabecular vBMD −7.3 %(−12.5 to −2.0)
WLH
difference in tibia trabecular vBMD −5.4 %(−9.1 to −1.7)
WLH
difference in radius cortical vBMD −3.5 %(−5.9 to −1.1)
WLH
difference in tibia cortical vBMD −1.1 %(−1.6 to −0.5)
Observational data: associations, not effects.
Further findings
HIV duration and radius bone measures (WLH)
- Longer HIV duration associated with lower radius bone area, BMC and bone strength estimates, independent of antiretroviral therapy (ART) duration
Original publication
Trabecular bone deficits predominate in the appendicular skeleton of midlife women living with HIV: findings from a cross-sectional study in Zimbabwe. J Bone Miner Res. Published 25 January 2025. doi:10.
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