The role of vitamin D metabolism in regulating bone turnover in adolescents with perinatally-acquired HIV in Southern Africa: a cross-sectional study in Zimbabwe and Zambia
Authors' conclusion
associations between 25(OH)D, PTH, 1,25(OH)2D, and BTMs in ALWH appear dependent upon 25(OH)D concentrations <75 nmol/L and calcium intake.
Study context
- Population
- Adolescents (11–19 yr) with perinatally-acquired HIV on antiretroviral therapy for ≥6 mo, Zimbabwe and Zambia
- Participants
- 842 adolescents
- Exposure
- 25D <75 vs ≥75 nmol/L
- Outcome
- Associations (structural equations modelling (SEM), standardized β) between vitamin D metabolites, intact PTH and bone turnover markers (BTMs), stratified by 25(OH)D <75 vs ≥75 nmol/L
- Follow-up
- Baseline
Methodological detailspre-planned secondary analysis of baseline trial data, structural equations modelling adjusted for age, sex and country
- Pre-planned secondary analysis of baseline trial data
- Structural equations modelling adjusted for age, sex and country
Main finding
As reported in the abstract
Parathyroid hormone (PTH) positively associated with 1,25(OH)2D when 25(OH)D <75 nmol/L: β
0.21 (0.1, 0.32) (95% CI)
PTH with 1,25(OH)2D when 25(OH)D ≥75 nmol/L: β
0.23 (−0.13, 0.59) (95% CI)
Interaction by 25(OH)D stratum, PTH–1,25(OH)2D: β
−0.11 (−0.20, −0.02) (95% CI)
Interaction between dietary calcium and 25(OH)D on PTH: β
−0.15 (−0.22, −0.07) (95% CI)
Observational data: associations, not effects.
Further findings
- Median dietary calcium intake (IQR)
- 100 mg (55-145)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →