Prevalence of HIV-associated osteoporosis and fracture risk in midlife women: a cross-sectional study in Zimbabwe
Authors' conclusion
While osteoporosis and previous fractures were common and untreated in this relatively young population, particularly in WLH, the FRAX-predicted 10-year MOF risk was low.
Study context
- Population
- Women aged 40–60 years in Harare, Zimbabwe (49% WLH); mean (SD) age 49.6 (5.8) years, mean (SD) BMI 29.1 (6.0) kg/m²; 95% of WLH antiretroviral therapy (ART) established, 81% viral load <50 copies/mL
- Participants
- 393 women
- Exposure
- Women with HIV vs women without HIV
- Outcome
- BMD T-score ≤ −2.5 (osteoporosis)
Main finding
As reported in the abstract
| Group | Value | Femoral neck (FN) | Lumbar spine (LS) |
|---|---|---|---|
| WLH | 11.4% | 22 [11.4%] | 40 [20.8%] |
| Without HIV | 2.5% | 5 [2.5%] | 9 [4.5%] |
Value
WLH11.4%
Without HIV2.5%
Femoral neck (FN)
WLH22 [11.4%]
Without HIV5 [2.5%]
Lumbar spine (LS)
WLH40 [20.8%]
Without HIV9 [4.5%]
Observational data: associations, not effects.
Further findings
Prior fracture, any type
Prior MOF
| Outcome | WLH | Without HIV | P value |
|---|---|---|---|
| FRAX 10-year MOF probability · higher with WLH | median 1.2% (IQR 0.9–1.8) | 1.0% (IQR 0.9–1.5) | P < 0.001 |
FRAX 10-year major osteoporotic fracture (MOF) probability
- Probabilities were low
Associations with FN BMD and MOF probability
- Older age, low weight and HIV infection strongly associated with lower FN BMD
- Higher MOF probability associated with older age, HIV infection, parental hip fracture and prior fracture; adjustment attenuated association with HIV
- No woman reported anti-osteoporosis medication use
Original publication
Prevalence of HIV-associated osteoporosis and fracture risk in midlife women: a cross-sectional study in Zimbabwe. J Bone Miner Res. Published 9 July 2024. doi:10.
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