Gestational diabetes & diabetes in pregnancy
Timing of gestational diabetes diagnosis and progression to type 2 Diabetes: A comparative analysis
Authors' conclusion
GDM diagnosis timing significantly impacts T2DM risk. 2nd trimester GDM carries the highest T2DM risk.
Study context
- Population
- Pregnant individuals with post-pregnancy follow-up, Meuhedet HMO data cross-tabulated with the Israeli National Diabetes Registry
- Participants
- 75,459 individuals
- Exposure
- Timing of GDM diagnosis: early vs 2nd trimester vs late GDM vs normoglycemic
- Outcome
- Progression to T2D
- Follow-up
- Median post-pregnancy 4.3 (IQR 3.3-5.1)
Methodological detailssurvival analysis, Cox regression adjusted for confounders
- Survival analysis
- Cox regression adjusted for confounders
Main finding
As reported in the abstract
T2D risk
- Group distribution: normoglycemic 90 %, early GDM 7.9 %, 2nd trimester GDM 1.4 %, late GDM 0.7 %
- 2nd trimester GDM showed the highest T2D risk annually after pregnancy
- Adjusted Cox regression: significantly higher T2D risk for 2nd trimester GDM vs early and late GDM
- Late GDM did not confer additional significant T2D risk
- Adjusted for confounders
Observational data: associations, not effects.
Further findings
T2D risk by obesity status
- Early GDM increased T2D risk only in individuals without obesity
Original publication
Timing of gestational diabetes diagnosis and progression to type 2 Diabetes: A comparative analysis. Diabetes Res Clin Pract. Published 11 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →