Gestational diabetes & diabetes in pregnancy

Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective and Longitudinal Study

Diabetes CarePublished Prospective nested case-control study

Authors' conclusion

This study suggests that GA concentrations in midpregnancy might be lower in women who later develop GDM. Further studies are needed to identify the mechanism.

Study context

Population
Pregnant women in the NICHD Fetal Growth Study; Glycated albumin (GA) measured at 10–14 and 15–26 weeks' gestation
Participants
107 vs 214
Comparison
Gestational diabetes mellitus (GDM) cases vs controls
  • GDMn = 107
  • Controln = 214reference
Outcome
GA concentrations and GDM risk
Methodological detailslongitudinal
  • Longitudinal

Main finding

As reported in the abstract

Mean GA · 15-26 weeks' gestation

Adjusted P value for difference = 0.004

Observational data: associations, not effects.

Further findings

GA concentrations and GDM risk

Higher GA tended to have lower GDM risk; associations not statistically significant

Original publication

Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective and Longitudinal Study. Diabetes Care. Published 5 July 2024. doi:10.2337/dc24-0668

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