Time trends towards earlier puberty in boys and girls with type 1 diabetes: Insights from the German Diabetes Prospective Follow‐up (DPV) registry, 2000 to 2021
Authors' conclusion
Our study highlights earlier puberty in children with T1D, influenced by BMI SDS, HbA1c level, and migration background. This has important implications for diabetes management and supporting healthy development. Further research is needed to understand the underlying mechanisms and develop potential interventions for this vulnerable population.
Study context
- Population
- Children with T1D aged 6 to 18 years, DPV registry, 2000 to 2021
- Participants
- 13,127 children
- Exposure
- Girls vs Boys
- Outcome
- Time trends in onset of puberty (girls: thelarche Tanner B2; boys: gonadarche Tanner G2/testicular volume >3 mL)
- Follow-up
- 2000 to 2021
Methodological detailsGerman Diabetes Prospective Follow-up (DPV) registry, stratified by sex
- German Diabetes Prospective Follow-up (DPV) registry
- Stratified by sex
Main finding
As reported in the abstract
Age at puberty onset, 2000 vs 2021
- Girls: thelarche (Tanner B2) age decreased from 11.48 (11.35-11.65) years in 2000 to 10.93 (10.79-11.08) years in 2021
- P < 0.001
- Boys: gonadarche (Tanner G2/testicular volume >3 mL) age decreased from 12.62 (12.42-12.82) years in 2000 to 11.98 (11.79-12.16) years in 2021
- P < 0.001
Observational data: associations, not effects.
Further findings
Factors associated with earlier puberty
- Longer diabetes duration, higher body mass index (BMI) standard deviation score (SDS) and lower HbA1c associated with earlier puberty in both sexes
- P < 0.001
Original publication
Time trends towards earlier puberty in boys and girls with type 1 diabetes: Insights from the German Diabetes Prospective Follow‐up (DPV) registry, 2000 to 2021. Diabetes Obes Metab. Published 12 October 2023. doi:10.
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