Trabecular bone score in adults with type 1 diabetes: a meta-analysis
Pooled result · TBSResult — go to the resultSMD - 0.37 95% CI - 0.52 to - 0.21Authors' conclusion
Adults with T1DM have a lower TBS but similar total hip and lumbar spine BMD compared to controls. The risk attributable to the significant but limited difference in TBS falls short of explaining the large excess propensity to fragility fracture in adults with T1DM. Further studies on clarification of the mechanism and whether TBS is suited to screen for fracture risk in adults with T1DM are necessary.
Study context
- Population
- Adults with T1D in cross-sectional and retrospective studies (PubMed, Scopus, Web of Science, all years)6 studies
- Participants
- 378 vs 286
- Comparison
- Adults with T1D vs controls
- T1DMn = 378
- Controlsn = 286reference
- Outcome
- TBS
Methodological detailsFracture risk not analysed: insufficient studies reporting it
- Fracture risk not analysed: insufficient studies reporting it
Pooled result
As reported in the abstract
SMD
- 0.37
95% CI - 0.52 to - 0.21
P < 0.00001
Further pooled results
| Outcome | SMD (95% CI) | P value |
|---|---|---|
| Lumbar spine BMDNo difference; 6 studies | - 0.06 (- 0.22 to 0.09) | P = 0.43 |
| Total hip BMDNo difference; 6 studies | - 0.17 (- 0.35 to 0.01) | P = 0.06 |
Original publication
Trabecular bone score in adults with type 1 diabetes: a meta-analysis. Osteoporos Int. Published 11 October 2023. doi:10.
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