Thyroid-joint crosstalk: a systematic review and meta-analysis of thyroid autoimmunity and dysfunction in juvenile idiopathic arthritis
Authors' conclusion
Thyroid dysfunction may be detected in children with JIA, with a significant risk difference in comparison to healthy controls.
Study context
- Population
- Children with juvenile idiopathic arthritis; 13,225 females (69.6%), weighted mean age 8.0 years (range 1.8–21 years); PubMed/Medline, Cochrane and Scopus
- Participants
- 19,015 children15 studies
- Comparison
- Children with juvenile idiopathic arthritis (JIA) vs controls
- JIAn = 19,015
- Outcome
- Prevalence of thyroid autoantibody positivity and thyroid dysfunction
Pooled result
As reported in the abstract
Pooled prevalence of antithyroid antibody positivity
0.04
95% CI 0.03–0.05
Pooled prevalence of thyroid dysfunction
0.04
95% CI 0.03–0.08
Further pooled results
| Outcome | Risk difference (95% CI) | |
|---|---|---|
| Thyroid autoantibody positivity, JIAvs controls | 0.08 (0.02–0.14) | |
| −0.100.10.2Difference (linear scale) |
Risk factors for thyroid autoantibody positivity and/or thyroid dysfunction in JIA
- Family history of thyroid autoimmune disease, OR
- 3.91 (95% CI 1.86-8.25)
- Concurrent Antinuclear Antibodies (ANA) positivity, OR
- 1.62 (95% CI 1.13-2.31)
- Older age, MD
- 2.10 years (95% CI 1.32-2.89)
- No significant difference for the specific JIA form
Original publication
Thyroid-joint crosstalk: a systematic review and meta-analysis of thyroid autoimmunity and dysfunction in juvenile idiopathic arthritis. J Clin Endocrinol Metab. Published 17 June 2026. doi:10.
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