Thyroid Hormones Exhibit Promising Prognostic and Therapeutic Potential in Autosomal Dominant Polycystic Kidney Disease
Authors' conclusion
This study reveals that THs contribute to ADPKD progression and identifies them as potential prognostic and therapeutic agents.
Study context
- Population
- Autosomal dominant polycystic kidney disease (ADPKD): patient-derived renal epithelial cells, PCK rats, and ADPKD patients enrolled in the REORIENTED clinical study
- Participants
- 90 ADPKD patients
- Comparison
- T4 vs vehicle; serum thyroid hormones (THs) vs eGFR
- Outcome
- Macrocystic area (%) in PCK rats
Methodological details3D polycystic tubule model from patient-derived renal epithelial cells, PCK rat model, clinical cohort correlation
- 3D polycystic tubule model from patient-derived renal epithelial cells
- PCK rat model
- Clinical cohort correlation
Main finding
As reported in the abstract
P < 0.05
Further findings
Correlation of serum reverse triiodothyronine (rT3) with renal function (eGFR), ADPKD patients
- rT3 inversely correlates with renal function, R2
- 0.159
- R
- −0.397
- P
- P < 0.001
Correlation of serum free triiodothyronine (fT3) with renal function (eGFR), ADPKD patients
- fT3 positively correlates with renal function, R2
- 0.110
- R
- 0.332
- P
- P < 0.01
Original publication
Thyroid Hormones Exhibit Promising Prognostic and Therapeutic Potential in Autosomal Dominant Polycystic Kidney Disease. Thyroid. Published 15 June 2026. doi:10.
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