The role of sex on the prevalence of cardiovascular risk factors in children and adolescents with Type 1 diabetes: The SWEET international database
Authors' conclusion
In children and adolescents with T1D, female sex, in addition to HbA1c above 7 %, and older age (>10 years) was associated with a higher risk of having at least a CVRF (LDL-C, BMI-SDS, BP) according to internationally defined cut-offs.
Study context
- Population
- Children and adolescents with T1D (6–18 years, T1D ≥ 2 years) in the SWEET prospective multicenter diabetes registry
- Participants
- 29,649 children
- Exposure
- Females vs males
- Outcome
- Prevalence of CVRFs (LDL-C > 100 mg/dL; systolic BP-SDS > 90th percentile; BMI-SDS > 2SD)
Methodological detailsmulticenter registry
- Multicenter registry
Main finding
As reported in the abstract
Prevalence of CVRFs
- ≥1 CVRF
- 41 %
- ≥2 cardiovascular risk factors (CVRFs)
- 10 %
- LDL-C > 100 mg/dL
- 35%
- BMI-SDS > 2SD
- 26 %
- Systolic BP-SDS > 90th percentile
- 17 %
Observational data: associations, not effects.
Further findings
≥1 CVRF by sex · higher with females
P < 0.001
≥2 CVRFs by sex · higher with females
P < 0.001
Factors associated with ≥1 or ≥2 CVRFs (multivariable logistic regression)
- Female sex, HbA1c >7.0 % and age >10 years associated with higher chance of ≥1 or ≥2 CVRFs
- P < 0.001
Original publication
The role of sex on the prevalence of cardiovascular risk factors in children and adolescents with Type 1 diabetes: The SWEET international database. Diabetes Res Clin Pract. Published 13 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →