Alterations of Sublingual Microcirculation in Children With Compensated Type 1 Diabetes Mellitus—An Observational Study
Authors' conclusion
Sublingual microcirculation examination using SDF imaging is feasible in children with type 1 diabetes. Alteration of sublingual microcirculatory parameters is detectable in children with type 1 diabetes before they show clinical or laboratory signs of any microvascular complication.
Study context
- Population
- Children with stable T1D without clinical or laboratory signs of microvascular complications; 15 males and 15 females in three age categories
- Participants
- 30 children
- Exposure
- Children with T1D vs healthy children
- T1Dn = 30
- Outcome
- Feasibility of sidestream dark-field (SDF) imaging and selected sublingual microcirculation parameters compared with healthy children
Main finding
As reported in the abstract
Feasibility and sublingual microcirculation parameters
- Videoclips successfully recorded in all children
- Total vessel density (TVD), small vessel density (SVD), perfused vessel density (PVD) and perfused SVD (PSVD) in both genders significantly lower in T1D vs healthy children
- De Backer score in females significantly lower in T1D vs healthy children
Observational data: associations, not effects.
Further findings
Microcirculation parameters by age and gender
- No differences in TVD, SVD, PVD, PSVD and De Backer score (DeBS) between age or gender categories
Correlations with other recorded parameters
- DeBS correlated with ketonemia; no other significant relationship between microcirculatory and other recorded parameters
Original publication
Alterations of Sublingual Microcirculation in Children With Compensated Type 1 Diabetes Mellitus—An Observational Study. Pediatr Diabetes. Published 30 September 2025. doi:10.
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