Continuous Glucose Monitoring and Long-Term Assessment of Islet Function in Autologous Islet Transplantation after Total Pancreatectomy for Neoplasm: Preliminary Insights from a Prospective Study
Authors' conclusion
CGM parameters reflect islet graft performance following TPIAT and are strongly correlated with established markers of β-cell function. Metrics such as TIR, TITR, TAR, CV, and GRI may serve as practical and sensitive tools for post-transplant metabolic surveillance in endocrine clinical practice.
Study context
- Population
- Patients with pancreatic neoplasms undergoing total pancreatectomy with islet autotransplantation (TPIAT), Verona University Hospital, September 2023–March 2025; male/female 5/5, median age 60 [IQR 55–68] years; median islet dose 1912 IEQ/kg [IQR 1724–3074]10 patients
- Participants
- 10 / 6 / 8 / 1
- Exposure
- Continuous glucose monitoring (CGM) metrics across Igls-defined islet graft function categories
- Optimaln = 10
- Goodn = 6
- Marginaln = 8
- Failuren = 1
- Outcome
- Relationship between CGM-derived glycemic metrics and islet function (Igls criteria, BETA-2 score)
- Follow-up
- 3, 6 and 12 months post-transplantation
Methodological detailssingle-centre, CGM data at 3 (n = 10), 6 (n = 8) and 12 (n = 7) months post-transplantation
- Single-centre
- CGM data at 3 (n = 10), 6 (n = 8) and 12 (n = 7) months post-transplantation
Main finding
As reported in the abstract
CGM metrics by Igls islet function category
| Group | TIR | TITR | TAR | CV | GRI |
|---|---|---|---|---|---|
| Optimal | 97.0% | 86.5% | 1.5% | 20.5% | 44.0 |
Optimal
TIR97.0%
TITR86.5%
TAR1.5%
CV20.5%
GRI44.0
- Optimal vs Good and Marginal: all P < 0.01 — superior glycemic control and lower glycemic variability with Optimal
- TIR, TITR, TAR, CV and GRI significantly correlated with both Igls classification and BETA-2 score
- all P < 0.015
Observational data: associations, not effects.
Further findings
Median
| Outcome | Optimal | Good | Marginal | Failure |
|---|---|---|---|---|
| Median BETA-2 score by Igls category | 19.4 | 13.6 | 5.3 | 1.4 |
- Median BETA-2 score by Igls category — Decreased significantly across groups
- P < 0.001
Original publication
Continuous Glucose Monitoring and Long-Term Assessment of Islet Function in Autologous Islet Transplantation after Total Pancreatectomy for Neoplasm: Preliminary Insights from a Prospective Study. Diabetes Technol Ther. Published 29 September 2025. doi:10.
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