Lower Prevalence of Diabetic Ketoacidosis at Diagnosis in Research Participants Monitored for Hyperglycemia
Authors' conclusion
While DKA prevalence increases in community patients over time, it stayed < 5% in active research participants, who have a 10 times lower prevalence of DKA at diagnosis, including among minorities.
Study context
- Population
- Patients <18 years diagnosed with T1D between 2005 and 2021 at the Barbara Davis Center for Diabetes
- Participants
- 5,049 patients
- Exposure
- Active study participants in preclinical monitoring studies vs community patients
- Active studyn = 164
- Inactive studyn = 42
- Communityn = 4,843reference
- Outcome
- Prevalence of DKA at T1D diagnosis
- Follow-up
- At diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
DKA at diagnosis
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Active study | Community | P value |
|---|---|---|---|
| Severe DKA at diagnosisActive study vs Community | 1.2% | 16.2% | P < 0.001 |
| HbA1c at diagnosisActive study vs Community · lower with active study participants | 7.3 % | 11.9 % | P < 0.001 |
| DKA prevalence in children <2 years · at diagnosis | 13% | 83% |
Temporal trend in diabetic ketoacidosis (DKA) prevalence · 2005–2021
- DKA prevalence increased in community patients
- from 44.0% to 55%
- Less evidence for a temporal trend in study participants
Factors associated with DKA at diagnosis in community patients
- Younger age
- P = 0.0038
- Public insurance
- P < 0.0001
- Rural residence
- P < 0.0076
- Higher HbA1c
- P < 0.0001
- Ethnicity minority status
- P < 0.0001
Original publication
Lower Prevalence of Diabetic Ketoacidosis at Diagnosis in Research Participants Monitored for Hyperglycemia. J Clin Endocrinol Metab. Published 12 March 2024. doi:10.
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