The Role of Muscular Fitness on Bone Mineral Content and Areal Bone Mineral Density in Youth With Type 1 Diabetes
Authors' conclusion
In pediatric patients with type 1 diabetes, higher muscular fitness could serve as a complementary therapeutic strategy to preserve or enhance bone health.
Study context
- Population
- Youth with T1D aged 6–18 years (44.6% girls), Diactive-1 cohort
- Participants
- 83 participants
- Outcome
- Association of muscular fitness (handgrip strength, 1 repetition maximum, muscle power) with bone mineral content (BMC) and areal bone mineral density (aBMD) (DXA) of TBLH, arms, legs, pelvis and spine
- Follow-up
- 2 years
Methodological detailslongitudinal, 2-year follow-up
- Longitudinal
- 2-year follow-up
Main finding
As reported in the abstract
Longitudinal associations of muscular fitness with TBLH bone parameters (linear mixed models)
- Handgrip strength with TBLH-BMC: B
- 17.18 (12.47-21.90) (95% CI)
- Handgrip strength with total body less head (TBLH)-aBMD: B
- 0.004 (0.002-0.006) (95% CI)
- RM with TBLH-BMC: B
- 20.09 (10.88-29.31) (95% CI)
- RM with TBLH-aBMD: B
- 0.007 (0.004-0.011) (95% CI)
- Power with TBLH-BMC: B
- 26.80 (17.31-36.28) (95% CI)
- Power with TBLH-aBMD: B
- 0.009 (0.005-0.012) (95% CI)
- Comparable results across the other regions
- P < .05
Observational data: associations, not effects.
Further findings
Standardized data: handgrip z-scores with TBLH bone z-scores
- Handgrip z-score with TBLH-BMC z-score: B
- 0.19 (0.08-0.30) (95% CI)
- Handgrip z-score with TBLH-aBMD z-score: B
- 0.350 (0.210-0.490) (95% CI)
Original publication
The Role of Muscular Fitness on Bone Mineral Content and Areal Bone Mineral Density in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. Published 5 June 2025. doi:10.
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