Compositional analysis of the association between 24 h movement behaviours, HbA1c and interstitial glucose in children and adolescents with type 1 diabetes mellitus: a two-year longitudinal analysis of the Diactive-1 cohort study
Authors' conclusion
Our findings indicate that lower sedentary behaviour and more optimal sleep and physical activity patterns are associated with greater metabolic stability in children and adolescents with type 1 diabetes. These findings support the need for further research on balancing these behaviours for better diabetes management, and encourage adoption of a 24 h movement approach in clinical care.
Study context
- Population
- Children and adolescents with T1D aged 6–18 years, 45% girls, Diactive-1 cohort; mean HbA1c 57.54 ± 9.22 mmol/mol (7.4 ± 0.8%), median interstitial glucose 9.37 mmol/l [IQR 8.68–10.31]
- Participants
- 83 children
- Outcome
- Association of physical activity, sedentarism and sleep with HbA1c and interstitial glucose (24 h compositional analysis)
- Follow-up
- 2 years
Methodological detailscompositional analysis, 2-year follow-up, accelerometer-measured 24 h movement behaviours, linear mixed models, Triaxial accelerometer for 9 days; HbA1c from medical records; interstitial glucose by CGM
- Compositional analysis
- 2-year follow-up
- Accelerometer-measured 24 h movement behaviours
- Linear mixed models
- Triaxial accelerometer for 9 days; HbA1c from medical records; interstitial glucose by CGM
Main finding
As reported in the abstract
- More sedentary behaviour (at expense of sleep, light or MVPA) and HbA1c: B (95% CI); β
- 14.077 (4.244, 23.956); 0.368
- More sedentary behaviour (at expense of sleep, light or MVPA) and interstitial glucose: B (95% CI); β
- 1.988 (0.153, 3.880); 0.261
- More sleep (at expense of sedentary, light or MVPA) and HbA1c: B (95% CI); β
- −12.712 (−25.204, −0.520); −0.197
- More MVPA (at expense of sedentary behaviour) and interstitial glucose: B (95% CI); β
- −1.580 (−2.800, −0.388); −0.283
- More MVPA (at expense of sedentary behaviour) and HbA1c: B (95% CI); β
- −9.361 (−15.856, −2.881); −0.330
Observational data: associations, not effects.
Original publication
Compositional analysis of the association between 24 h movement behaviours, HbA1c and interstitial glucose in children and adolescents with type 1 diabetes mellitus: a two-year longitudinal analysis of the Diactive-1 cohort study. Diabetologia. Published 31 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →