Safety and Efficacy of an Adaptive Bolus Calculator for Type 1 Diabetes: A Randomized Controlled Crossover Study
Authors' conclusion
The ABC4D is safe for adapting insulin bolus doses and provided the same level of glycemic control as the nonadaptive bolus calculator.
Study context
- Population
- Adults with T1D on MDI; median (IQR) age 44.7 (28.2–55.2) years, diabetes duration 15.0 (9.5–29.0) years, HbA1c 61.0 (58.0–67.0) mmol/mol (7.7 [7.5–8.3]%)33 analysed
- Participants
- 37 adults
- Comparison
- ABC4D adaptive bolus calculator vs nonadaptive bolus calculator
- Primary endpoint
- Difference between groups in change in daytime (07:00-22:00) %TIR (3.9-10.0 mmol/L [70-180 mg/dL])
Methodological detailsprospective, 2-week run-in, 6-week washout
- Prospective
- 2-week run-in
- 6-week washout
Primary result
As reported in the abstract
Change in daytime %TIR
ABC4D
+0.1
median · IQR −2.6 to +4.0 · %
Control
+1.9
median · IQR −3.8 to +10.1 · %
P = 0.53
Further findings
Meal dose recommendations accepted · fewer accepted with ABC4D
P = 0.009
Meal dose recommendations accepted
- Greater reduction in insulin dosage from that recommended with ABC4D
Original publication
Safety and Efficacy of an Adaptive Bolus Calculator for Type 1 Diabetes: A Randomized Controlled Crossover Study. Diabetes Technol Ther. Published 29 May 2023. doi:10.
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