The Frequency of Undiagnosed Celiac Disease in Youth with Type 1 Diabetes and Its Association with Diabetic Retinopathy: The SEARCH for Diabetes in Youth Study
Authors' conclusion
Undiagnosed CD is likely present in youths with type 1 diabetes and potentially undiagnosed CD is associated with a higher risk of diabetic retinopathy. These findings indicate the importance of routine screening for CD in type 1 diabetes in youths.
Study context
- Population
- Youths with childhood-onset T1D who completed a celiac disease (CD) questionnaire and underwent tissue transglutaminase autoantibody (tTGA) testing, SEARCH for Diabetes in Youth study
- Participants
- 2,444 participants
- Exposure
- Youths with T1D by CD status and tTGA levels
- Outcome
- Frequency of CD and potential for undiagnosed CD
Methodological detailsPoisson model to estimate relative risk
- Poisson model to estimate relative risk
Main finding
As reported in the abstract
Frequency of CD
Observational data: associations, not effects.
Further findings
| Outcome | RR |
|---|---|
| Diabetic retinopathyPotentially undiagnosed CD vs Type 1 diabetes only · higher risk with potentially undiagnosed CD | 2.69 |
HbA1c
- CD with tTGA <0.05 (controlled CD) associated with lower HbA1c
Original publication
The Frequency of Undiagnosed Celiac Disease in Youth with Type 1 Diabetes and Its Association with Diabetic Retinopathy: The SEARCH for Diabetes in Youth Study. Pediatr Diabetes. Published 29 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →