Fully closed‐loop control with ultra‐rapid versus standard insulin lispro: A randomised crossover study simulating missed meal boluses
Authors' conclusion
URIL in a fully closed-loop setting showed a clinically meaningful trend towards improved TIR and reduced hyperglycaemia compared to IL. Further advancements in faster-acting insulins are needed to alleviate the burden of pre-meal bolusing and enhance fully closed-loop performance in the future.
Study context
- Population
- Adults with T1D using insulin pump therapy; 12 females, age 39.1 (14.2) yrs, HbA1c 57.9 (8.7) mmol/mol; two 8-h inpatient sessions with standardised meal without meal bolus17 analysed
- Participants
- 18 adults
- Comparison
- Ultra-rapid insulin lispro (URIL) vs standard insulin lispro (IL) in fully closed-loop control without meal bolus
- Primary endpoint
- Percentage of time in range (TIR) (3.9-10 mmol/L) based on sensor glucose
- Follow-up
- 8-h study period
Methodological detailsopen-label, inpatient
- Open-label
- Inpatient
Primary result
As reported in the abstract
TIR
P = 0.072
Further findings
Time in Level 1 hyperglycaemia (>10 mM) · 8-h study period
P = 0.098
Time in Level 2 hyperglycaemia (>13.9) · 8-h study period
P = 0.136
4-h post-meal period
- Similar trends were observed in the 4-h post-meal period
Safety
| Outcome | P value |
|---|---|
| Time in hypoglycaemia · 8-h study periodLow and comparable | P > 0.05 |
Time in hypoglycaemia · 8-h study period
- Time in hypoglycaemia was low and comparable between both periods
Original publication
Fully closed‐loop control with ultra‐rapid versus standard insulin lispro: A randomised crossover study simulating missed meal boluses. Diabet Med. Published 15 August 2025. doi:10.
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