Sex-specific thresholds of peak oxygen consumption for detecting cardiometabolic risk in children and adolescents with type 1 diabetes
Authors' conclusion
Our study supports the clinical utility of these thresholds as a non-invasive marker of metabolic health and reinforce the importance of cardiorespiratory fitness promotion in this population.
Study context
- Population
- Children and adolescents aged 8–18 years with T1D, Diactive-1 cohort; external validation in a Brazilian cohort (n = 36)62 completed 2-year follow-up
- Participants
- 83 children
- Comparison
- Boys vs Girls
- Outcome
- Sex-specific VO2peak thresholds discriminating cardiometabolic risk:
- Z-score of waist circumference
- Lipid profile
- HbA1c
- Blood pressure
Methodological detailsexternal validation cohort, 2-year follow-up
- External validation cohort
- 2-year follow-up
Performance
As reported in the abstract
Optimal VO2peak threshold for CMR
| Test or model | Value | AUC |
|---|---|---|
| Boys | 40.8 ml/kg/min | 0.71 |
| Girls | 33.7 ml/kg/min | 0.78 |
Value
Boys40.8 ml/kg/min
Girls33.7 ml/kg/min
AUC
Boys0.71
Girls0.78
Further findings
Lipids and overall cardiometabolic risk (CMR) below thresholds
- Participants below thresholds had significantly higher lipids and overall CMR
Persistence and external validation · 2-year follow-up
- Associations persisted at 2-year follow-up and were confirmed in the Brazilian cohort, which also showed elevated HbA1c among high-risk individuals
Original publication
Sex-specific thresholds of peak oxygen consumption for detecting cardiometabolic risk in children and adolescents with type 1 diabetes. Diabetes Res Clin Pract. Published 8 August 2025. doi:10.
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