Associations of Continuous Glucose Monitoring (CGM) Metrics With Stimulated C-Peptide Measures in Youth With Recent-Onset Type 1 Diabetes
Authors' conclusion
CGM measures correlated with stimulated C-peptide measures; however, the strength of the correlations and sensitivity and specificity of CGM-derived measures were not great enough to replace C-peptide measures in clinical trials.
Study context
- Population
- Children with recent-onset T1D, time points up to 52 weeks after diagnosis
- Participants
- 103 children
- Exposure
- CGM metrics vs mixed-meal tolerance test-derived stimulated C-peptide
- Outcome
- Spearman correlation of CGM metrics with C-peptide AUC
- Follow-up
- 52 weeks
Main finding
As reported in the abstract
TIR 70-180 mg/dL
0.45
Time <70 mg/dL
−0.33
Glucose CV
−0.58
Multivariate model of these 3 metrics
0.63
Observational data: associations, not effects.
Further findings
Prediction of peak C-peptide ≥0.2 pmol/mL by the 3-metric combination
- Sensitivity
- 68.4%
- Specificity
- 75%
Original publication
Associations of CGM Metrics With Stimulated C-Peptide Measures in Youth With Recent-Onset Type 1 Diabetes. Diabetes Care. Published 4 June 2025. doi:10.
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