The relationship between bone strain index, bone mass, microarchitecture and mechanical behavior in human vertebrae: an ex vivo study
Authors' conclusion
The BSI was significantly correlated with the microarchitecture and mechanical behavior of L3 vertebrae, and these associations remained statistically significant regardless of aBMD.
Study context
- Population
- Fresh lumbar vertebrae (L3) harvested from human donors
- Participants
- 31 human donors
- Outcome
- Correlations of BSI with mechanical behavior, bone mass and microarchitecture
Methodological detailscadaveric human L3 vertebrae, DXA, µCT (35-µm voxel) and quasi-static uniaxial compressive testing
- Cadaveric human L3 vertebrae
- DXA, µCT (35-µm voxel) and quasi-static uniaxial compressive testing
Main finding
As reported in the abstract
- Bone Strain Index (BSI) vs failure load, r
- −0.60 (p < 0.0001)
- BSI vs stiffness, r
- −0.59 (p < 0.0001)
- BSI vs aBMD, r
- −0.93 (p < 0.0001)
- BSI vs BMC, r
- −0.86 (p < 0.0001)
- BSI vs Tb.BV/TV, r
- −0.58 (p = 0.001)
- BSI vs structure model index (SMI), r
- 0.51 (p = 0.004)
Further findings
Partial correlations adjusted for aBMD
- BSI vs stiffness, r
- −0.51 (p = 0.004)
- BSI vs SMI, r
- −0.39 (p = 0.03)
- BSI vs failure load, r (close to significance)
- −0.35 (p = 0.06)
- Partial correlations
Original publication
The relationship between bone strain index, bone mass, microarchitecture and mechanical behavior in human vertebrae: an ex vivo study. Osteoporos Int. Published 23 March 2024. doi:10.
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