The Prevalence of Polyneuropathy in Type 2 Diabetes Subgroups Based on HOMA2 Indices of β-Cell Function and Insulin Sensitivity
Main finding · DPN prevalenceResult — go to the resultAdjusted prevalence ratio 1.35 95% CI 1.15–1.57Authors' conclusion
Hyperinsulinemia marked by high HOMA2-B is likely an important risk factor for DPN beyond metabolic syndrome components and insulin resistance. This should be considered when developing interventions to prevent DPN.
Study context
- Population
- Danish patients with newly diagnosed T2D3,397 filled in Michigan Neuropathy Screening Instrument questionnaire (MNSIq)
- Participants
- 4,388 patients
- Exposure
- Hyperinsulinemic vs classical vs insulinopenic T2D subgroups
- Outcome
- Prevalence of DPN (Michigan Neuropathy Screening Instrument questionnaire score ≥ 4)
- Follow-up
- Median 3 years
Methodological detailsnewly diagnosed T2D, median follow-up 3 years, Poisson regression, spline models
- Newly diagnosed T2D
- Median follow-up 3 years
- Poisson regression
- Spline models
Main finding
DPN prevalence
Adjusted prevalence ratio
1.35
95% CI 1.15–1.57
By group
Hyperinsulinemicvs Classical
adjusted PR 1.35 (95% CI 1.15–1.57)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Diabetic polyneuropathy (DPN) prevalence by HOMA2-B (spline analyses)
- Linear relation of higher DPN prevalence with increasing HOMA2-B, independent of metabolic syndrome components and HOMA2-S
Original publication
The Prevalence of Polyneuropathy in Type 2 Diabetes Subgroups Based on HOMA2 Indices of β-Cell Function and Insulin Sensitivity. Diabetes Care. Published 19 June 2023. doi:10.
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