Albuminuria predicts diabetic retinopathy and consequences of polyneuropathy in individuals with type 2 diabetes and chronic kidney disease: an observational nationwide Danish cohort study
Authors' conclusion
Albuminuria was associated with a progressive increase in prevalence and incidence of microvascular disease in individuals with type 2 diabetes and CKD.
Study context
- Population
- Adults with T2D and chronic kidney disease (CKD) (eGFR < 60 ml min⁻1 1.73 m²⁻1), Danish health care registers 2010–2023; median age 75 years (IQR 69–80), 41.5% female, median eGFR 53 ml min⁻1 1.73 m²⁻1 (IQR 47–56)
- Participants
- 27,924 adults
- Exposure
- Urine albumin-creatinine-ratio (UACR) strata
- Outcome
- Prevalence and incidence of microvascular complications: diabetic retinopathy, polyneuropathy and CKD progression
- Follow-up
- 5-year risks
Methodological detailsobservational, Danish health care registers, Logistic regression for baseline odds; Cox regression for standardized 5-year risks
- Observational
- Danish health care registers
- Logistic regression for baseline odds; Cox regression for standardized 5-year risks
Main finding
As reported in the abstract
- ORs for diabetic retinopathy and polyneuropathy were positively correlated with UACR
- 5-year risks of all outcomes were similarly associated with increasing UACR levels
Observational data: associations, not effects.
Original publication
Albuminuria predicts diabetic retinopathy and consequences of polyneuropathy in individuals with type 2 diabetes and chronic kidney disease: an observational nationwide Danish cohort study. Diabetes Res Clin Pract. Published 17 May 2026. doi:10.
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