Severe hypoglycaemia in adults presenting to a hospital emergency department: Clinical characteristics, comorbidities, and mortality outcomes
Authors' conclusion
Severe hypoglycaemia requiring emergency hospital treatment is associated with non-cardiovascular deaths and exerts a disproportionately greater impact on mortality in people with T2D and those without diabetes. Multimorbidity is an important risk factor for SH and increases mortality risk.
Study context
- Population
- Adults presenting with severe hypoglycaemia (SH) to the ED of Northern General Hospital, Sheffield, UK over 44 months
- Participants
- 506 adults619 SH episodes
- Exposure
- T1D vs T2D vs non-DM patients presenting with severe hypoglycaemia
- T1Dn = 172reference
- T2Dn = 216
- non-DMn = 110
- Outcome
- Clinical characteristics, comorbidities and mortality outcomes, including cause of death
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Mortality after index SH episode
| Group | Value | Median time to death |
|---|---|---|
| T1D | 13.3% | 465 days |
| T2D | 38.0% | 113 days |
| non-DM | 39.1% | 13 days |
Value
T1D13.3%
T2D38.0%
non-DM39.1%
Median time to death
T1D465 days
T2D113 days
non-DM13 days
- non-DM vs T1D: all P < 0.05 — higher mortality, lower survival with non-DM
- T2D vs T1D: all P < 0.05 — higher mortality, lower survival with T2D
- Most deaths from non-CV causes
- 78%-86%
- Charlson index predicted mortality and poor survival in T1D and T2D
- both P < 0.05
Observational data: associations, not effects.
Further findings
Hospital admission and inpatient LOS
- Hospital admission and inpatient LOS — Hospital admission
- 60%-75%
Socioeconomic deprivation and comorbidities
- T2D had more deprivation and comorbidities, irrespective of age of diabetes onset
- P < 0.005
Young-onset T2D share of SH episodes in diabetes
- Young-onset T2D share of all episodes in diabetes
- 7.2%
Original publication
Severe hypoglycaemia in adults presenting to a hospital emergency department: Clinical characteristics, comorbidities, and mortality outcomes. Diabetes Obes Metab. Published 19 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →