Associations of Diabetic Retinopathy Severity With High Ambulatory Blood Pressure and Suppressed Serum Renin Levels
Authors' conclusion
Severe DR was associated with higher 24-hour BPs and suppressed ARC. These findings suggest that mineralocorticoid receptor overactivation may play a role in higher BP levels and severe DR in diabetic patients.
Study context
- Population
- Diabetic patients classified by diabetic retinopathy (DR) severity on funduscopic examination
- Exposure
- Severe DR vs no DR or simple DR
- Outcome
- 24-hour ambulatory BP
Main finding
As reported in the abstract
- Severe DR had significantly higher 24-hour blood pressure (BPs), incl. daytime and nighttime systolic and diastolic BP, vs no DR or simple DR, independent of diabetic duration and HbA1c
- Nighttime systolic BP variability greater in severe DR than nonsevere DR; nocturnal BP reduction similar
- Ambulatory BPs significantly inversely associated with ARC
Observational data: associations, not effects.
Further findings
pg/mL
| Outcome | No DR | Severe DR | P value |
|---|---|---|---|
| Serum active renin (ARC)Severe DR vs No DR or simple DR · ARC lower in severe DR · spread printed in brackets; kind not stated | 9.8 (range 4.6–18.0) | 3.2 (range 1.5–13.6) | P < 0.05 |
Serum active renin (ARC)
- No differences in SAC in patients taking calcium channel blockers and/or α-blockers
Other hormones (ACTH, cortisol)
- No associations between DR severity and other hormone levels
Original publication
Associations of Diabetic Retinopathy Severity With High Ambulatory Blood Pressure and Suppressed Serum Renin Levels. J Clin Endocrinol Metab. Published 15 June 2023. doi:10.
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