Effect of preoperative SGLT2 inhibitor use on postoperative acute kidney injury in patients with type 2 diabetes undergoing surgery: A causal inference study using routinely collected data
Main finding · Postoperative AKIResult — go to the resultAdjusted odds ratio 0.71 95% CI 0.56–0.91Authors' conclusion
In patients with type 2 diabetes who used SGLT2i preoperatively, its use reduced the odds of postoperative acute kidney injury.
Study context
- Population
- Patients with T2D undergoing surgery under general anaesthesia, tertiary centre in Australia; over half underwent emergency surgery
- Participants
- 2,499 patients
- Comparison
- Preoperative SGLT2i use vs no preoperative SGLT2i
- SGLT2in = 738
- No SGLT2in = 1,761reference
- Outcome
- Postoperative acute kidney injury (AKI)
- Follow-up
- Within 7 days of surgery
Methodological detailsinverse probability of treatment weighting, single tertiary centre
- Inverse probability of treatment weighting
- Single tertiary centre
Main finding
As reported in the abstract
Adjusted odds ratio
0.71
95% CI 0.56–0.91
P = 0.007
By group
SGLT2ivs No SGLT2i
adjusted OR 0.71 (95% CI 0.56–0.91); P = 0.007
Further findings
- Effects were consistent across subgroup and sensitivity analyses
Original publication
Effect of preoperative SGLT2 inhibitor use on postoperative acute kidney injury in patients with type 2 diabetes undergoing surgery: A causal inference study using routinely collected data. Diabetes Obes Metab. Published 29 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →