Cardiovascular Autonomic Neuropathy and Indices of Heart Failure in Type 2 Diabetes: The CANCAN Study
Main finding · Elevated NT-proBNP > 125 pg/mLResult — go to the resultOdds ratio 6.2 95% CI 2.1–20.8Authors' conclusion
CAN is associated with elevated NT-proBNP levels in individuals asymptomatic for HF.
Study context
- Population
- Individuals with T2D recruited from two Danish outpatient clinics, 2021–2024; median age 63 years, 61% men, median diabetes duration 17 years134 with valid cardiovascular autonomic neuropathy (CAN) assessment
- Participants
- 200 individuals
- Exposure
- CAN vs no CAN
- Outcome
- Elevated NT-proBNP levels > 125 pg/mL
Methodological detailstwo Danish outpatient clinics
- Two Danish outpatient clinics
Main finding
Elevated NT-proBNP > 125 pg/mL
Odds ratio
6.2
95% CI 2.1–20.8
By group
CANvs No CAN
OR 6.2 (95% CI 2.1–20.8)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) in subgroups: asymptomatic individuals and low-to-moderate WATCH-DM risk score
- Association of CAN with elevated NT-proBNP remained statistically significant in asymptomatic individuals and in those with a low-to-moderate WATCH-DM risk score
Original publication
Cardiovascular Autonomic Neuropathy and Indices of Heart Failure in Type 2 Diabetes: The CANCAN Study. Diabetes Obes Metab. Published 28 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →