Gestational diabetes & diabetes in pregnancy
The Interplay of Persistent Organic Pollutants and Mediterranean Diet in Association With the Risk of Gestational Diabetes Mellitus
Main finding · GDM riskResult — go to the resultAdjusted log-odds ratio −0.74 95% CI −1.41 to −0.07Authors' conclusion
Pregnant women who consumed a healthy Mediterranean diet but had a low exposure to POP concentrations had the lowest GDM risk. Future endeavors to promote a healthy diet to prevent GDM may consider concurrent POP exposure.
Study context
- Population
- Pregnant women in the U.S. Fetal Growth Study; Alternate Mediterranean diet (aMED) score from FFQs at early pregnancy; plasma concentrations of 76 persistent organic pollutants (POPs) measured61 with gestational diabetes mellitus (GDM)
- Participants
- 1,572 women
- Exposure
- Combined aMED score and POP exposure categories
- Outcome
- GDM risk
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
As reported in the abstract
Adjusted log-odds ratio
−0.74
95% CI −1.41 to −0.07
Observational data: associations, not effects.
Further findings
GDM incidence
- Women with GDM
- 61 of 1,572 (3.88%)
POP detection
- Included POPs with detection rate >50%
- 25 of 53
Other POPs
- Inverse associations also observed among women with low aMED score and high TransNo_chlor, PCB182_187, PCB196_203, PCB199 and PCB206
Subgroup: overweight or obesity
- Associations more pronounced among women with overweight or obesity
Original publication
The Interplay of Persistent Organic Pollutants and Mediterranean Diet in Association With the Risk of Gestational Diabetes Mellitus. Diabetes Care. Published 9 October 2024. doi:10.
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