The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications—2023 Diabetes , Diabetes Care , and Diabetologia Expert Forum
Recommendations
As issued by the authors
The gut microbiota (GM) may be involved in the pathophysiology of T2D: microbially produced metabolites associate both positively and negatively with the disease, and mechanistic links of GM functions (e.g., butyrate-production genes) with glucose metabolism have emerged through Mendelian randomization in humans
The highly individualized nature of the GM is a major research obstacle; large cohorts and a deep-sequencing metagenomic approach are required for robust assessments of associations and causation
Single-time point sampling misses intraindividual GM dynamics; future studies with repeated measures within individuals are needed
Much future research is required to determine the applicability of this knowledge to diabetes diagnosis and treatment; novel technologies and improved computational tools will be important
Original publication
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