Effects of home-based exercise training on gut microbiota and possible relations with cognitive function and metabolic health in postmenopausal women with type 2 diabetes mellitus: a randomized control trial
Authors' conclusion
This study supports the potential effectiveness of multi-task exercise programs in enhancing physical fitness and metabolic health in postmenopausal women with T2DM. The findings also suggest a possible connection between the gut and the brain, with Akkermansia muciniphila emerging as a potential mediator. Investigating the Akkermansia-to-brain pathway represents a promising and emerging area of research that warrants further exploration.
Study context
- Population
- Postmenopausal women with T2D
- Participants
- 70 women
- Comparison
- 12-week home-based multi-task exercise vs control
Primary result
As reported in the abstract
Gut microbiota composition · 12 weeks
- Exercise training significantly increased Akkermansia muciniphila and Faecalibacterium levels and reduced Lactobacillus abundance (p < 0.05)
Further findings
High-density lipoprotein (HDL), cognitive function and physical fitness
- Improvements in HDL levels, cognitive function and physical fitness (p < 0.05)
Correlation of increased Akkermansia abundance with improvements
- Correlation with HDL improvement
- r = 0.41
- Correlation with cognitive function improvement
- r = 0.49
Original publication
Effects of home-based exercise training on gut microbiota and possible relations with cognitive function and metabolic health in postmenopausal women with type 2 diabetes mellitus: a randomized control trial. Diabetes Res Clin Pract. Published 17 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →