The gut microbiota and diabetes: research, translation, and clinical applications – 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum
Recommendations
As issued by the authors
Gut microbiota (GM) may be involved in T2D pathophysiology: microbially produced metabolites associate positively and negatively with the disease; Mendelian randomisation in humans has linked GM functions (e.g. butyrate-production genes) with glucose metabolism
The highly individualised GM is a major research obstacle; large cohorts and deep-sequencing metagenomics are required for robust assessment of association and causation
Single time point sampling misses intraindividual GM dynamics; future studies with repeated measures within individuals are needed
Much future research is required to apply this knowledge to diabetes diagnosis and treatment; novel technologies and improved computational tools will be important
Original publication
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