The dose-response association between wearables-quantified incidental physical activity and type 2 diabetes: a prospective cohort study
Authors' conclusion
MIPA and VIPA were associated with lower T2D risk in a dose-dependent manner. Although median LIPA was linked to reduced risk, it did not demonstrate a consistent dose-response relationship.
Study context
- Population
- Self-reported nonexercising adults, UK Biobank accelerometry sub-study, without T2D at baseline; mean age 62.1 ± 7.7 years, 42.8% male
- Participants
- 22,857 nonexercisers
- Exposure
- Intensity-specific incidental physical activity vs neither MIPA nor VIPA
- Outcome
- Incident T2D (primarily from primary care records)
- Follow-up
- 7.8-year follow-up
Methodological detailsdevice-measured physical activity (accelerometry)
- Device-measured physical activity (accelerometry)
Main finding
As reported in the abstract
Incident T2D
Each group vs referenceHazard ratio (95% CI)
VIPAmedian VIPA (4.75 minutes/day)
0.62(0.53–0.73)
MIPAmedian MIPA (23.70 minutes/day)
0.67(0.52–0.86)
- Developed T2D (all participants)
- 721 (3.2%)
Observational data: associations, not effects.
Further findings
T2D-specific equivalence of 1 minute of VIPA/day
- Equivalent T2D risk reduction in MIPA
- 5.9 minutes MIPA/day
- Equivalent T2D risk reduction in LIPA
- 46.6 minutes LIPA/day
Original publication
The dose-response association between wearables-quantified incidental physical activity and type 2 diabetes: a prospective cohort study. J Clin Endocrinol Metab. Published 24 September 2026. doi:10.
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