Equivalent Acute Anti‐Inflammatory Effects of Exercise in Type 2 Diabetes Versus Healthy Adults: A Randomised Crossover Study
Authors' conclusion
This study identifies hs-CRP as a key baseline biomarker differentiating well-controlled T2D from healthy adults. Acute exercise induces transient, cytokine-specific modulation rather than a generalised anti-inflammatory effect. IL-6 dynamics may be influenced by exercise duration, fitness and temperature, informing personalised prescription.
Study context
- Population
- Patients with T2D and healthy adults completing three exercise trials: A (moderate-intensity aerobic, resistance and combined), B (resistance at low, moderate, vigorous intensities), C (combined at low, moderate, vigorous intensities)
- Participants
- 21 vs 26
- Comparison
- Acute inflammatory response to guideline-based exercise in T2D vs healthy adults
- T2Dn = 21
- Healthy adultsn = 26reference
- Primary endpoint
- Circulating hs-CRP, IL-6, IL-8, TNF-α and leukocyte count
- Follow-up
- Baseline (fasting), immediately after and 72 h post-exercise (fasting)
Methodological detailsthree-period crossover, ≥ 72-h washout, repeated-measures ANCOVA with age as covariate
- Three-period crossover
- ≥ 72-h washout
- Repeated-measures ANCOVA with age as covariate
Primary result
As reported in the abstract
Inflammatory biomarkers
- Trial B: IL-8 significantly lowered immediately post-exercise
- p = 0.048
- Trial B: TNF-α significantly lowered immediately post-exercise
- p < 0.001
- Trial A: significant group × time interaction for leukocyte count
- p = 0.034
Original publication
Equivalent Acute Anti‐Inflammatory Effects of Exercise in Type 2 Diabetes Versus Healthy Adults: A Randomised Crossover Study. Diabetes Obes Metab. Published 10 March 2026. doi:10.
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