The association between the visceral obesity indices and the future diabetes mellitus risk: A prospective cohort study
Authors' conclusion
Visceral obesity indices are closely linked to the risk of diabetes onset, highlighting the potential benefits of reducing visceral fat accumulation. Among these indices, LAP emerges as the most robust clinical indicator for predicting DM risk.
Study context
- Population
- Participants aged ≥40 years without baseline diabetes
- Participants
- 6,575 participants
- Exposure
- Five visceral obesity indices and incident diabetes mellitus (DM)
- Outcome
- Diabetes onset
- Follow-up
- Average 3.19 years
Main finding
As reported in the abstract
Incident diabetes
| Group | HR | AUC |
|---|---|---|
| Lipid accumulation product (LAP) | 2.93 (95% CI 2.27-4.01) | 0.752 |
Lipid accumulation product (LAP)
HR2.93 (95% CI 2.27-4.01)
AUC0.752
- Developed diabetes
- 752 (11.4%)
- LAP showed the strongest association
- HR = 2.93, 95% CI = 2.27-4.01
- LAP had the optimal predictive efficacy
- AUC = 0.752
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic splines (RCS))
- Nonlinear dose-response relationship
Stratified and sensitivity analyses
- High stability of the LAP–diabetes association
Original publication
The association between the visceral obesity indices and the future diabetes mellitus risk: A prospective cohort study. Diabetes Obes Metab. Published 28 May 2025. doi:10.
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