Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE
Primary result · Time to first hospitalizationResult — go to the resultHazard ratio 0.78 95% CI 0.66–0.92Authors' conclusion
Hospitalizations were common in GRADE, and rates were nearly identical across treatment groups. The small, but significant, reduction in risk for subsequent hospitalizations among participants assigned to liraglutide versus glimepiride may influence treatment decisions in populations similar to GRADE participants.
Study context
- Population
- GRADE participants taking metforminITT
- Participants
- 5,047 participants
- Comparison
- Insulin glargine U-100 vs glimepiride vs liraglutide vs sitagliptin, added to metformin
- Primary endpoint
- Incidence of time to first hospitalization
Methodological detailscomparative effectiveness, intention-to-treat and on-assigned-treatment data sets
- Comparative effectiveness
- Intention-to-treat and on-assigned-treatment data sets
Primary result
Time to first hospitalization
Hazard ratio
0.78
95% CI 0.66–0.92
P = 0.022
Liraglutidevs Glimepiride
HR 0.78 (95% CI 0.66–0.92); P = 0.022
As reported in the abstract
- Hospitalized at least once
- 1,636 (32.4%)
- Hospitalized more than once
- 751 (14.9%)
Secondary outcomes
Hospitalization during GRADE
- Hospitalized at least once
- 1,636 (32.4%)
- Hospitalized more than once
- 751 (14.9%)
Risk factors for subsequent hospitalizations
- Meeting secondary outcome (HbA1c >7.5%, confirmed): increase in risk
- 29%
- Each prior hospitalization: increase in risk
- 41%
- Change from assigned treatment: increase in risk
- 56%
- Liraglutide vs glimepiride: reduction in risk
- 13%
Characteristics of hospitalized participants · baseline
- Hospitalized participants were older, less likely Hispanic, more likely White, more likely to have hypertension history, and had higher baseline BMI
Original publication
Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE. Diabetes Care. Published 27 May 2025. doi:10.
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