Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study
Main finding · Future endpoints (multivariable Cox regression)Result — go to the resultHazard ratio 1.91 95% CI 1.06–3.44Authors' conclusion
T2DM patients with OCAD showed distinct RV functional impairments and worse long-term outcomes compared to those without OCAD, including more severe RV systolic and diastolic dysfunction and a significantly higher risk of adverse clinical outcomes.
Study context
- Population
- Patients with T2DM with or without obstructive coronary artery disease, and control subjects246 T2DM, 85 controls
- Participants
- 105 / 141 / 85
- Exposure
- T2DM with vs without obstructive coronary artery disease
- T2DM(obstructive coronary artery disease (OCAD)+)n = 105
- T2DM(OCAD-)n = 141reference
- Controln = 85
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
- Overall composite outcome
- Follow-up
- Median 5.7 (3.1, 6.7) years
Methodological detailscardiovascular magnetic resonance
- Cardiovascular magnetic resonance
Main finding
Future endpoints (multivariable Cox regression) · median follow-up 5.7 years
Hazard ratio
1.91
95% CI 1.06–3.44
P = 0.031
T2DM(OCAD+)vs T2DM(OCAD-)
HR 1.91 (95% CI 1.06–3.44); P = 0.031
As reported in the abstract
Observational data: associations, not effects.
Further findings
Right ventricular (RV) global circumferential PS (GCPS), GLPS and PSSR-L
- Decreased progressively from controls to T2DM(OCAD-) to T2DM(OCAD+)
- all P < 0.05
Association of OCAD with impaired RV strain in T2DM
- GRPS β
- - 0.186
- GCPS β
- - 0.121
- GLPS β
- - 0.153
- PSSR-L β
- - 0.165
- PDSR-R β
- - 0.133
Original publication
Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study. Cardiovasc Diabetol. Published 26 May 2025. doi:10.
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