Incremental effect of coronary obstruction on myocardial microvascular dysfunction in type 2 diabetes mellitus patients evaluated by first-pass perfusion cardiac magnetic resonance (CMR) study
Authors' conclusion
Coronary artery obstruction in the context of T2DM exacerbated myocardial microcirculation damage. The presence of OCAD and Gensini score were independent predictors of decreased microvascular function.
Study context
- Population
- T2DM patients with or without obstructive coronary artery disease, and controls, undergoing CMR297 T2DM, 89 controls
- Participants
- 188 / 109 / 89
- Exposure
- T2DM with obstructive coronary artery disease (OCAD) vs T2DM without OCAD vs controls
- T2DM(OCAD -)n = 188
- T2DM(OCAD +)n = 109
- Controln = 89reference
- Outcome
- CMR perfusion parameters (upslope, max signal intensity (MaxSI), TTM) in global and segmental slices
Methodological detailsCMR first-pass perfusion
- CMR first-pass perfusion
Main finding
As reported in the abstract
- From controls through T2DM(OCAD +) with Gensini score ≤ 64 to Gensini score > 64, upslope declined and TTM prolonged progressively in global and mid-ventricular slice
- all P < 0.05
Observational data: associations, not effects.
Further findings
Independent predictors of microvascular dysfunction in T2DM (multivariable linear regression)
- OCAD presence vs global upslope (β)
- - 0.104, P < 0.05
- OCAD presence vs global TTM (β)
- 0.105, P < 0.05
Gensini score vs global TTM in T2DM(OCAD +)
- Correlation (r)
- 0.34, P < 0.001
Original publication
Incremental effect of coronary obstruction on myocardial microvascular dysfunction in type 2 diabetes mellitus patients evaluated by first-pass perfusion CMR study. Cardiovasc Diabetol. Published 28 June 2023. doi:10.
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