The association between sex hormones and the change in brain‐predicted age difference in older women
Authors' conclusion
No strong evidence of an association between circulating sex hormones and brain-PAD. Given there is prior evidence to suggests sex hormones may be important for brain ageing, further studies of circulating sex hormones and brain health in postmenopausal women are warranted.
Study context
- Population
- Community-dwelling older women (aged 70+ years) not taking medications known to influence sex hormone concentrations
- Participants
- 207 women
- Exposure
- Circulating sex hormone concentrations and brain-predicted age difference (brain-PAD)
- Outcome
- Brain-PAD (brain-predicted age difference) at baseline and its longitudinal change, brain age derived from whole brain volume on T1-weighted MRI
- Follow-up
- Baseline, 1 and 3 years
Methodological detailssubstudies of the ASPREE clinical trial (NEURO and Sex Hormones in Older Women)
- Substudies of the ASPREE clinical trial (NEURO and Sex Hormones in Older Women)
Main finding
As reported in the abstract
Brain-PAD
- Higher baseline brain-PAD (older brain age) in highest vs lowest dehydroepiandrosterone (DHEA) tertile, unadjusted analysis
- p = .04
Observational data: associations, not effects.
Original publication
The association between sex hormones and the change in brain‐predicted age difference in older women. Clin Endocrinol (Oxf). Published 27 February 2023. doi:10.
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