Dietary Inflammatory Index and Fractures in Midlife Women: Study of Women's Health Across the Nation
Authors' conclusion
A more pro-inflammatory diet in pre- and early perimenopause is a risk factor for incident fracture. Future studies should consider whether reducing dietary inflammation in midlife diminishes fracture risk.
Study context
- Population
- Pre- or early perimenopausal women, Study of Women's Health Across the Nation; women using bone-beneficial medications at baseline excluded
- Participants
- 1,559 participants
- Exposure
- Greater vs lower dietary inflammatory index
- Outcome
- Incident fracture
- Follow-up
- Up to 20 years
Methodological detailsCox proportional hazards regression, up to 20 years of follow-up, Subsequent initiators of bone-beneficial medications censored at first use
- Cox proportional hazards regression
- Up to 20 years of follow-up
- Subsequent initiators of bone-beneficial medications censored at first use
Main finding
As reported in the abstract
Fracture hazard per SD increment
Greater fracture hazard per SD increment in E-DII
28%
P = .005
Greater fracture hazard per SD increment in E-DII-S
21%
P = .02
Observational data: associations, not effects.
Further findings
Fracture hazard after controlling for BMD
- Associations essentially unchanged after controlling for BMD
Original publication
Dietary Inflammatory Index and Fractures in Midlife Women: Study of Women's Health Across the Nation. J Clin Endocrinol Metab. Published 13 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →