Family building after diagnosis of premature ovarian insufficiency: a cross-sectional survey in 324 women
Authors' conclusion
Having children after a diagnosis of POI is not uncommon but more often results from oocyte donation. This study will provide enlightened information for newly diagnosed women on the possibilities to build a family after POI diagnosis.
Study context
- Population
- Women who consulted for premature ovarian insufficiency (POI) in the endocrinology and reproductive medicine department at la Pitié Salpêtrière, 1991–2021; excluding Turner syndrome, POI secondary to oncological treatment, and age <18 at survey985 referred
- Participants
- 324 women
- Outcome
- Proportion of women with POI who built a family after diagnosis, and the alternative chosen
Methodological detailsdescriptive, survey, single-centre, Survey Jun–Sep 2021 of patients followed up or contacted by mail or phone
- Descriptive
- Survey
- Single-centre
- Survey Jun–Sep 2021 of patients followed up or contacted by mail or phone
Main finding
As reported in the abstract
Children after POI diagnosis among women who wanted to build a family
- Had children after diagnosis (of women who wanted a family)
- 41%
- By oocyte donation
- 53.9%
- By embryo donation
- 1 woman
- After ovarian stimulation
- 5.6%
- By adoption
- 13.5%
- Spontaneous pregnancy, after a mean time of 2.5 years
- 25.8%
Observational data: associations, not effects.
Further findings
Spontaneous pregnancy rate in the whole cohort
- Spontaneous pregnancy rate
- 8.6%
Original publication
Family building after diagnosis of premature ovarian insufficiency: a cross-sectional survey in 324 women. Eur J Endocrinol. Published 10 February 2023. doi:10.
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