Fertility and pregnancy outcomes in women with Turner syndrome: A single centre experience
Authors' conclusion
We show that pregnancy in women with TS, whether OD or spontaneously conceived, carries obstetric risks, and therefore, women with TS, considering pregnancy, should receive comprehensive pre-pregnancy counselling and optimal obstetric care.
Study context
- Population
- Women with Turner syndrome (TS) undergoing oocyte donation (OD) treatment or spontaneous pregnancy, large single-centre cohort
- Exposure
- OD pregnancies vs spontaneous pregnancies in women with TS; OD in TS vs women with POI
- ODn = 74
- Spontaneousn = 31reference
- Outcome
- Lower segment caesarean section (LSCS) and small for gestational age (SGA), OD vs spontaneous pregnancies in TS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
OD vs SpontaneousOdds ratio (95% CI)P value
LSCS
4.19(1.6–10.8)
P = 0.003SGA
2.92(1.02–8.38)
P = 0.04Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Live birth rate per cycle started, OD in TSvs POILower with OD in TS | 0.53 (0.34–0.84) | P = 0.008 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | OD | POI | P value |
|---|---|---|---|
| Miscarriage, OD in TS vs POI | 40% | 26.2% | P = 0.04 |
Vertical transmission of TS in daughters
- Cases of vertical transmission of TS in daughters
- 5 (17.2%)
Safety
- Recorded cardiac events
- 0
Original publication
Fertility and pregnancy outcomes in women with Turner syndrome: A single centre experience. Clin Endocrinol (Oxf). Published 27 May 2024. doi:10.
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