Femora of women with premature ovarian insufficiency exhibit reduced strength and misalignment with the transmitted vertical forces from the upper body
Authors' conclusion
Alongside lower BMD at multiple sites, the femora of women with POI demonstrate reduced strength and a misalignment with forces transmitted from the upper body. Further research is needed to establish the role of these newly identified features and their role in fracture risk prediction in this population.
Study context
- Population
- Women aged 20–50 years with s-POI or iatrogenic POI (i-POI); median age at premature ovarian insufficiency (POI) diagnosis 35 (18–40) years; mean POI duration at DXA 2.07 (range 0–13) years; 84% received oestrogen therapymatched case-control
- Participants
- 89 vs 89
- Comparison
- Women with POI vs matched controls
- POIn = 89
- Controlsn = 89reference
- Outcome
- Hip/femur anatomy, strength, geometry and femoral alignment by advanced hip analysis (AHA) on hip DXA images
Methodological detailsage- and body mass index (BMI)-matched population-based controls
- Age- and BMI-matched population-based controls
Main finding
As reported in the abstract
| Group | Value | Femoral orientation angle (FOA) |
|---|---|---|
| POI | 139.30 ± 29.08 mm² | 124.99 ± 3.18 |
| Controls | 157.29 ± 22.26 mm² | 128.04 ± 3.80 |
Value
POI139.30 ± 29.08 mm²
Controls157.29 ± 22.26 mm²
Femoral orientation angle (FOA)
POI124.99 ± 3.18
Controls128.04 ± 3.80
- POI vs Controls: P < 0.001 — cross-sectional area (CSA) lower with POI
- POI vs Controls: P < 0.001 — section modulus (SM) lower with POI
- POI vs Controls: P < 0.001 — FOA smaller with POI
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Areal BMD at all sitesLower with POI | all P < .05 |
Areal bone mineral density (BMD) at all sites
- Areal BMD at all sites significantly lower in POI
Original publication
Femora of women with premature ovarian insufficiency exhibit reduced strength and misalignment with the transmitted vertical forces from the upper body. Eur J Endocrinol. Published 8 December 2023. doi:10.
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