Associations of Serum Testosterone and Sex Hormone-binding Globulin With Incident Arrhythmias in Men From UK Biobank
Authors' conclusion
Lower levels of testosterone and cFT were associated with increased risk of AF and BA. Higher cFT levels were associated with increased risk of AF and VA. Higher SHBG levels were associated with increased risk of AF, VA, and BA.
Study context
- Population
- Men aged 37–73 years from UK Biobank with sex hormones measured at baseline, followed for 11 years
- Participants
- 173,498 men
- Exposure
- Categories of serum testosterone, cFT and SHBG
- Outcome
- Incidence of AF/flutter, ventricular arrhythmia (VA) and bradyarrhythmia (BA)
- Follow-up
- 11 years
Methodological detailspopulation-based (UK Biobank), multivariable adjustment
- Population-based (UK Biobank)
- Multivariable adjustment
Main finding
As reported in the abstract
Incident AF, VA and BA by testosterone, cFT and SHBG
Each group vs third quartileHazard ratio (95% CI)
Lowest testosterone categoryAF; multivariable adjusted
1.06(1.00–1.12)
Lowest testosterone categoryBA; multivariable adjusted
1.11(1.02–1.20)
Higher cFTAF
1.07(1.02–1.13)
Higher cFTVA
1.18(1.01–1.37)
Higher SHBGAF
1.44(1.34–1.54)
Higher SHBGVA
1.27(1.07–1.52)
Higher SHBGBA
1.17(1.05–1.29)
- Incident atrial fibrillation/flutter (AF)
- 11 368
- Incident ventricular arrhythmia (VA)
- 1646
- Incident bradyarrhythmia (BA)
- 4788
Observational data: associations, not effects.
Original publication
Associations of Serum Testosterone and Sex Hormone-binding Globulin With Incident Arrhythmias in Men From UK Biobank. J Clin Endocrinol Metab. Published 4 September 2023. doi:10.
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