Temporal trends in macrovascular complications in young-onset diabetes in Korea: A nationwide population-based study
An erratum to this article was published (Diabetes Res Clin Pract, Aug 2026 ↗)
Authors' conclusion
Despite declining incidence, macrovascular complications remain a substantial burden in young-onset diabetes, particularly in early adulthood and type 2 diabetes, highlighting the need for early cardiovascular risk management.
Study context
- Population
- Individuals diagnosed with diabetes before age 30 years, Korean Health Insurance Review and Assessment Service data (2008–2021)
- Participants
- 6,432 vs 71,615
- Exposure
- T1D vs T2D
- T1Dn = 6,432
- T2Dn = 71,615
- Outcome
- Age-standardized incidence and prevalence of macrovascular complications
- Follow-up
- 2008-2021
Methodological detailstime-dependent Cox models, segmented regression, Poisson regression
- Time-dependent Cox models
- Segmented regression
- Poisson regression
Main finding
As reported in the abstract
Incidence of macrovascular complications (per 10,000 persons) · 2008 to 2021
- T1D: incidence declined from 72.1 to 35.5 per 10,000 persons
- T2D: incidence declined from 169.5 to 71.4
- Prevalence remained substantial
Observational data: associations, not effects.
Further findings
Risk factors for macrovascular complications
- T1D: older age at diagnosis, low socioeconomic status, hypertension, dyslipidemia and comorbidity burden increased risk
- T2D: older age at diagnosis, low socioeconomic status, hypertension, mental and thyroid disorders and comorbidity burden increased risk
Incidence during COVID-19 pandemic
- Incidence increased only in T2D
Original publication
Temporal trends in macrovascular complications in young-onset diabetes in Korea: A nationwide population-based study. Diabetes Res Clin Pract. Published 28 April 2026. doi:10.
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