Cardiovascular Complications, Kidney Failure, and Mortality in Young-Onset Type 1 and Type 2 Diabetes: Data From the Korean National Health Insurance Service
Authors' conclusion
In South Korea, patients with young-onset diabetes are at high risk of cardiovascular complications, kidney failure, and death.
Study context
- Population
- Patients aged ≤30 years with T1D or T2D, Korean National Health Insurance Service-National Sample Cohort database, 2006–2019
- Participants
- 513,633 patients
- Exposure
- Young-onset T1D and T2D vs general population controls
- T1Dn = 413
- T2Dn = 1,250
- Controln = 511,970reference
- Outcome
- All-cause mortality and incidence of cardiovascular complications (MI, stroke) and kidney failure
Methodological detailsnationwide registry database, adjusted for sex, age, family income, hypertension and dyslipidemia
- Nationwide registry database
- Adjusted for sex, age, family income, hypertension and dyslipidemia
Main finding
As reported in the abstract
MI, stroke, kidney failure and all-cause mortality (adjusted HR vs control)
Each group vs controlEstimate (95% CI)
T1D
HR for MI 6.76(2.44–18.72)
T2D
HR for MI 5.07(2.48–10.36)
T1D
HR for stroke 4.65(1.70–12.71)
T2D
HR for stroke 3.30(1.67–6.53)
T1D
HR for kidney failure 20.92(11.40–38.39)
T2D
HR for kidney failure 2.78(1.37–5.64)
Mortality risk
- T1D · significantly higher
- 3.69 (95% CI 1.95–6.98)
- T2D · significantly higher
- 3.06 (95% CI 2.02–4.63)
Observational data: associations, not effects.
Further findings
| Outcome | Mortality risk (95% CI) |
|---|---|
| Mortality risk, T2D subgroup aged <20 years at enrollmentT2D vs Control · highest; aged <20 years at enrollment | 10.70 (4.41–25.94) |
Original publication
Cardiovascular Complications, Kidney Failure, and Mortality in Young-Onset Type 1 and Type 2 Diabetes: Data From the Korean National Health Insurance Service. Diabetes Care. Published 23 December 2024. doi:10.
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