Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis
Authors' conclusion
This study revealed different associations between trace elements and the risk of mid and end DKD using both single and mixture effect modeling. The results suggested that the urinary trace element profile might be associated with the progression of DKD, which provides important insights for understanding the pathogenesis of DKD and developing individualized nutritive management strategies.
Study context
- Population
- Diabetic patients; urinary trace elements measured by inductively coupled plasma mass spectrometry
- Participants
- 830 patients
- Exposure
- Diabetic kidney disease (DKD) vs non-DKD
- Outcome
- Associations between nine essential urinary trace elements and DKD
Methodological detailscase and control matched on age and sex
- Case and control matched on age and sex
Main finding
As reported in the abstract
- Urinary Cu and manganese (Mn) significantly higher in DKD than NDKD
- Urinary Fe, cobalt, selenium and nickel (Ni) lower in DKD
- Positive correlations between urinary Mn/Cu and risk of mid-stage and end-stage DKD (conditional logistic regression)
- Fe and Ni negatively associated with risk of DKD
Observational data: associations, not effects.
Further findings
Joint trace element exposure (mixed effect analyses)
- No significant trend for joint trace element exposure and risk of mid DKD
- Negative associations between combined effects of trace elements and risk of end DKD
Original publication
Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis. BMJ Open Diabetes Res Care. Published 20 December 2024. doi:10.
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