Temporal trends in treatment-requiring microvascular complications in young-onset diabetes: A nationwide population-based study
Authors' conclusion
Treatment-requiring microvascular complications in young-onset diabetes declined in Korea, but persistent age- and socioeconomic-related disparities highlight the need for equitable prevention and management.
Study context
- Population
- Individuals diagnosed with diabetes before age 30 years, Korean Health Insurance Review and Assessment Service data, 2008–2021
- Participants
- 6,202 vs 77,815
- Exposure
- T1D vs T2D
- T1Dn = 6,202
- T2Dn = 77,815
- Outcome
- Trends in treatment-requiring microvascular complications (diagnostic codes with relevant prescriptions or procedures): age-standardized incidence and prevalence
- Follow-up
- 2008-2021
Methodological detailsage-standardized incidence and prevalence (Poisson regression), time-dependent Cox models
- Age-standardized incidence and prevalence (Poisson regression)
- Time-dependent Cox models
Main finding
As reported in the abstract
Treatment-requiring microvascular complications, incidence and prevalence
T1D incidence declined (per 1,000 persons)
from 32.2 to 12.0
T2D incidence declined steadily
from 31.4 to 12.4
T2D prevalence declined steadily
from 72.6 to 43.1
Observational data: associations, not effects.
Further findings
Risk factors for treatment-requiring microvascular complications
- T1D: young adulthood, female sex and hypertension increased risk
- T2D: young adulthood, male sex, low socioeconomic status and greater comorbidity burden were key predictors
Original publication
Temporal trends in treatment-requiring microvascular complications in young-onset diabetes: A nationwide population-based study. Diabetes Res Clin Pract. Published 4 June 2026. doi:10.
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