Gestational diabetes & diabetes in pregnancy
Targeted metabolomics reveals novel biomarkers for gestational diabetes mellitus
Authors' conclusion
We identified abnormal serum metabolites caused by GDM, which may contribute to our understanding of the pathomechanisms of GDM.
Study context
- Population
- Pregnant women with or without gestational diabetes mellitus (GDM); serum metabolites
- Comparison
- Women with GDM vs normal pregnancy
- Outcome
- Differential serum metabolites, GDM vs normal pregnancy
Methodological detailstargeted metabolomics
- Targeted metabolomics
Main finding
As reported in the abstract
Differential metabolites
46
Upregulated
24
Downregulated
22
Observational data: associations, not effects.
Further findings
Correlation of metabolites with maternal glucose
- Metabolites associated with fasting blood glucose
- 2
- Metabolites correlated with 1-h postprandial plasma glucose
- 22
- Metabolites related to 2-h postprandial plasma glucose
- 13
- Most metabolites closely related to maternal glucose level
Diagnostic performance for GDM (ROC)
- Metabolites with AUC above 0.75: 2-hydroxybutyric acid, itaconic acid, O-acetylcarnitine, glutathione disulfide, P-cresolsulfate, 2-furoic acid, l-asparagine, d-biotin, choline, homovanillic acid
Original publication
Targeted metabolomics reveals novel biomarkers for gestational diabetes mellitus. Diabetes Obes Metab. Published 30 January 2025. doi:10.
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